In silico functional analysis of DNA repair proteins (OGG1, MYH) in Arabidopsis thaliana

Abstract

Deoxyribonucleic acid (DNA) is a hereditary material found in every living organism. However, every organism is exposed to endogenous and exogenous an agent which causes damage to DNA molecules. Even though genetic variation is important for evolution, every organism requires genetic stability for survival. Not only it is needed for DNA to replicate accurately but also several DNA repair mechanisms are used to fix the damage which occurred in DNA. A detailed structure analysis along with docking site and metabolic pathway prediction were used to confirm that these proteins are involved in DNA repair mechanisms. This study investigated OGG1 and MYH proteins from Arabidopsis thaliana, and showed their interaction with predicted partners, focusing on their detailed interactome and 3D structure predictions. This study concluded that OGG1 and MYH are not only found in DNA repair mechanisms but also show strong functions in DNA replication and the development of plant and cell cycle.