An in silico prediction of IRGQ and TRIM21 interactions – autophagy related proteins

Abstract

Autophagy is an intracellular process that is important for the detection and cleansing of the degraded cellular material, which accumulation can lead to cancer. Autophagy can also be beneficial in the detection and destruction of cancer cells in early stages of cancer, but in late stages, by the implementation of IRGQ protein, it can use the immune system as a tool for enhancing the proliferation and expansion of cancer cells, making the human organism more vulnerable. Implementation of the TRIM21 protein in interacting with IRGQ can be a promising tool to prevent the hostile function of the IRGQ protein and prevent cancer from immune evasion. This paper predicts the 3D structures of these proteins and, by the implementation of docking, reveals the possible immune system enhancement when fighting cancer.